Human factors design interventions have been suggested to mitigate infection risk in health care. Among such solutions, many are easily identified and theoretically simple and quick to realize. These are called low-hanging fruit. We present a case of infection risk associated with syringe manipulation that could easily be solved by introducing user-centered design solutions. Yet, organizational complexity makes implementation of such solutions hardly reachable. We therefore advocate embedding human factors macroergonomic expertise on an organizational level.