Abstract
Purpose: Zero echo time (ZTE) imaging with single-pulse excitation is a fast, robust, and silent three-dimensional (3D) method for MRI of short T2 tissues. In this technique, algebraic reconstruction serves to fill gaps in the center of k-space due to finite acquisition dead time. The purpose of this study was to investigate the effect of this operation on depiction characteristics, noise behavior, and achievable bandwidth.
Methods: The spatial response function (SRF) and noise covariance resulting from ZTE reconstruction were studied using formal analysis, simulations, and phantom experiments.
Results: Three prominent limiting phenomena were identified: SRF behavior within the field of view, heightened sensitivity to out-of-band signal sources, and noise amplification. The related errors all appear as image distortions of low spatial frequency and are strongly attenuated upon the transition from one-dimensional projections to 3D image data. Relying on these observations, ZTE imaging was accomplished with a previously unreached gap size, permitting the depiction of a solid sample with T2 ≈ 25 µs at a bandwidth of 500 kHz.
Conclusion: The tightest bandwidth limits in ZTE arise from background signal and radiofrequency (RF) switching transients. Significant advances in ZTE performance will be afforded by faster transmit-receive (T/R) switching with negligible transients and RF coils free of background signal.
Weiger, Markus