AIM: To compare engraftment rates and vascularisation in a rat model using either Integra Artificial Skin or Matriderm. METHODS: Matriderm and the dermal part of Integra were compared in a two-step procedure including matrix implantation and subsequent epidermal grafting. Neonatal rat epidermis was used as coverage to test for rapid and complete take. RESULTS: Efficiency and quality of vascularisation expressed by take rate of epidermis, and thickness of resulting neodermis, were identical for both matrices. CONCLUSION: This first comparison of Matriderm with Integra in a rat model revealed no major differences in engraftment rates or vascularisation.