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Wuillemin, Michel A; Stuber, Wanda T; Fox, Thomas; Reber, Michael J; Brühwiler, Dominik; Alberto, Roger; Braband, Henrik (2014). A novel $^{99m}$Tc labelling strategy for the development of silica based particles for medical applications. Dalton Transactions, 43(11):4260.
The reaction of high-valent fac-{$^{99m}$TcO$_3$}+ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Physical Sciences > Inorganic Chemistry |
| Language: | English |
| Date: | 2014 |
| Deposited On: | 20 Feb 2015 09:49 |
| Last Modified: | 12 Mar 2025 02:40 |
| Publisher: | RSC Publishing |
| ISSN: | 1477-9226 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1039/c3dt53019a |
Wuillemin, Michel A