Header

UZH-Logo

Maintenance Infos

Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection


Asquith, Christopher R M; Meli, Marina L; Konstantinova, Lidia S; Laitinen, Tuomo; Poso, Antti; Rakitin, Oleg A; Hofmann-Lehmann, Regina; Allenspach, Karin; Hilton, Stephen T (2015). Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection. Bioorganic & Medicinal Chemistry Letters, 25(6):1352-1355.

Abstract

A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.

Abstract

A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.

Statistics

Citations

Dimensions.ai Metrics
13 citations in Web of Science®
16 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

153 downloads since deposited on 19 Feb 2015
7 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
05 Vetsuisse Faculty > Center for Clinical Studies
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Life Sciences > Biochemistry
Life Sciences > Molecular Medicine
Life Sciences > Molecular Biology
Life Sciences > Pharmaceutical Science
Life Sciences > Drug Discovery
Life Sciences > Clinical Biochemistry
Physical Sciences > Organic Chemistry
Uncontrolled Keywords:FIV, HIV, Tetrathiocenes, Nucleocapsid, Zinc finger
Language:English
Date:2015
Deposited On:19 Feb 2015 17:45
Last Modified:26 Jan 2022 05:20
Publisher:Elsevier
ISSN:0960-894X
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.bmcl.2014.12.047
PubMed ID:25702849
  • Content: Accepted Version