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Asquith, Christopher R M; Meli, Marina L; Konstantinova, Lidia S; Laitinen, Tuomo; Poso, Antti; Rakitin, Oleg A; Hofmann-Lehmann, Regina; Allenspach, Karin; Hilton, Stephen T (2015). Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection. Bioorganic & Medicinal Chemistry Letters, 25(6):1352-1355.
A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
05 Vetsuisse Faculty > Center for Clinical Studies |
| Dewey Decimal Classification: | 570 Life sciences; biology
630 Agriculture |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Molecular Biology Life Sciences > Pharmaceutical Science Life Sciences > Drug Discovery Life Sciences > Clinical Biochemistry Physical Sciences > Organic Chemistry |
| Uncontrolled Keywords: | FIV, HIV, Tetrathiocenes, Nucleocapsid, Zinc finger |
| Language: | English |
| Date: | 2015 |
| Deposited On: | 19 Feb 2015 17:45 |
| Last Modified: | 12 Sep 2024 01:38 |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| OA Status: | Green |
| Publisher DOI: | https://doi.org/10.1016/j.bmcl.2014.12.047 |
| PubMed ID: | 25702849 |
Asquith, Christopher R M