Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Can infant lung function predict respiratory morbidity during the first year of life in preterm infants?

Proietti, Elena; Riedel, Thomas; Fuchs, Oliver; Pramana, Isabelle; Singer, Florian; Schmidt, Anne; Kuehni, Claudia; Latzin, Philipp; Frey, Urs (2014). Can infant lung function predict respiratory morbidity during the first year of life in preterm infants? European Respiratory Journal, 43(6):1642-1651.

Abstract

Compared with term-born infants, preterm infants have increased respiratory morbidity in the first year of life. We investigated whether lung function tests performed near term predict subsequent respiratory morbidity during the first year of life and compared this to standard clinical parameters in preterms. The prospective birth cohort included randomly selected preterm infants with and without bronchopulmonary dysplasia. Lung function (tidal breathing and multiple-breath washout) was measured at 44 weeks post-menstrual age during natural sleep. We assessed respiratory morbidity (wheeze, hospitalisation, inhalation and home oxygen therapy) after 1 year using a standardised questionnaire. We first assessed the association between lung function and subsequent respiratory morbidity. Secondly, we compared the predictive power of standard clinical predictors with and without lung function data. In 166 preterm infants, tidal volume, time to peak tidal expiratory flow/expiratory time ratio and respiratory rate were significantly associated with subsequent wheeze. In comparison with standard clinical predictors, lung function did not improve the prediction of later respiratory morbidity in an individual child. Although associated with later wheeze, noninvasive infant lung function shows large physiological variability and does not add to clinically relevant risk prediction for subsequent respiratory morbidity in an individual preterm.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pulmonary and Respiratory Medicine
Language:English
Date:June 2014
Deposited On:12 Feb 2015 14:36
Last Modified:13 Oct 2024 01:37
Publisher:European Respiratory Society
ISSN:0903-1936
OA Status:Closed
Publisher DOI:https://doi.org/10.1183/09031936.00149213
PubMed ID:24696112

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
30 citations in Web of Science®
36 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 12 Feb 2015
0 downloads since 12 months

Authors, Affiliations, Collaborations

Similar Publications