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Dummer, Reinhard; Goldinger, Simone M; Widmer, Daniel; Dreier, Jil; Levesque, Mitchell P (2014). To B-(RAF) or not to be. Journal of Investigative Dermatology, 134(5):1200-1201.
The identification of targetable mutations has revolutionized the therapy of metastatic melanoma. In particular, BRAF and MEK inhibitors have a well-documented impact on overall survival in metastatic disease. However, therapeutic success is highly dependent on the correct identification of these mutations. We discuss the impact of molecular heterogeneity in this context.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Biology Health Sciences > Dermatology Life Sciences > Cell Biology |
| Language: | English |
| Date: | May 2014 |
| Deposited On: | 26 Feb 2015 11:43 |
| Last Modified: | 13 Jan 2025 02:37 |
| Publisher: | Elsevier |
| ISSN: | 0022-202X |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1038/jid.2014.62 |
| PubMed ID: | 24732335 |
Dummer, Reinhard