Header

UZH-Logo

Maintenance Infos

Clinical evaluation of PET image quality as a function of acquisition time in a new TOF-PET/MRI compared to TOF-PET/CT-initial results


Zeimpekis, Konstantinos G; Barbosa, Felipe; Hüllner, Martin; Ter Voert, Edwin; Davison, Helen; Veit-Haibach, Patrick; Delso, Gaspar (2015). Clinical evaluation of PET image quality as a function of acquisition time in a new TOF-PET/MRI compared to TOF-PET/CT-initial results. Molecular Imaging and Biology, 17(5):735-744.

Abstract

PURPOSE: The purpose of this study was to compare only the performance of the PET component between a TOF-PET/CT (henceforth noted as PET/CT) scanner and an integrated TOF-PET/MRI (henceforth noted as PET/MRI) scanner concerning image quality parameters and quantification in terms of standardized uptake value (SUV) as a function of acquisition time (a surrogate of dose). The CT and MR image quality were not assessed, and that is beyond the scope of this study.
PROCEDURES: Five brain and five whole-body patients were included in the study. The PET/CT scan was used as a reference and the PET/MRI acquisition time was consecutively adjusted, taking into account the decay between the scans in order to expose both systems to the same amount of the emitted signal. The acquisition times were then retrospectively reduced to assess the performance of the PET/MRI for lower count rates. Image quality, image sharpness, artifacts, and noise were evaluated. SUV measurements were taken in the liver and in the white matter to compare quantification.
RESULTS: Quantitative evaluation showed strong correlation between PET/CT and PET/MRI brain SUVs. Liver correlation was good, however, with lower uptake estimation in PET/MRI, partially justified by bio-redistribution. The clinical evaluation showed that PET/MRI offers higher image quality and sharpness with lower levels of noise and artifacts compared to PET/CT with reduced acquisition times for whole-body scans while for brain scans there is no significant difference.
CONCLUSION: The TOF-PET/MRI showed higher image quality compared to TOF-PET/CT as tested with reduced imaging times. However, this result accounts mainly for body imaging, while no significant differences were found in brain imaging.

Abstract

PURPOSE: The purpose of this study was to compare only the performance of the PET component between a TOF-PET/CT (henceforth noted as PET/CT) scanner and an integrated TOF-PET/MRI (henceforth noted as PET/MRI) scanner concerning image quality parameters and quantification in terms of standardized uptake value (SUV) as a function of acquisition time (a surrogate of dose). The CT and MR image quality were not assessed, and that is beyond the scope of this study.
PROCEDURES: Five brain and five whole-body patients were included in the study. The PET/CT scan was used as a reference and the PET/MRI acquisition time was consecutively adjusted, taking into account the decay between the scans in order to expose both systems to the same amount of the emitted signal. The acquisition times were then retrospectively reduced to assess the performance of the PET/MRI for lower count rates. Image quality, image sharpness, artifacts, and noise were evaluated. SUV measurements were taken in the liver and in the white matter to compare quantification.
RESULTS: Quantitative evaluation showed strong correlation between PET/CT and PET/MRI brain SUVs. Liver correlation was good, however, with lower uptake estimation in PET/MRI, partially justified by bio-redistribution. The clinical evaluation showed that PET/MRI offers higher image quality and sharpness with lower levels of noise and artifacts compared to PET/CT with reduced acquisition times for whole-body scans while for brain scans there is no significant difference.
CONCLUSION: The TOF-PET/MRI showed higher image quality compared to TOF-PET/CT as tested with reduced imaging times. However, this result accounts mainly for body imaging, while no significant differences were found in brain imaging.

Statistics

Citations

Dimensions.ai Metrics
18 citations in Web of Science®
22 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

23 downloads since deposited on 22 Apr 2015
23 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Health Sciences > Radiology, Nuclear Medicine and Imaging
Life Sciences > Cancer Research
Language:English
Date:4 April 2015
Deposited On:22 Apr 2015 15:44
Last Modified:26 Jan 2022 06:08
Publisher:Springer
ISSN:1536-1632
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s11307-015-0845-5
PubMed ID:25840683

Download

Green Open Access

Download PDF  'Clinical evaluation of PET image quality as a function of acquisition time in a new TOF-PET/MRI compared to TOF-PET/CT-initial results'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 1MB
View at publisher