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Identity-specific coding of future rewards in the human orbitofrontal cortex


Howard, James D; Gottfried, Jay A; Tobler, Philippe N; Kahnt, Thorsten (2015). Identity-specific coding of future rewards in the human orbitofrontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 112(16):5195-5200.

Abstract

Nervous systems must encode information about the identity of expected outcomes to make adaptive decisions. However, the neural mechanisms underlying identity-specific value signaling remain poorly understood. By manipulating the value and identity of appetizing food odors in a pattern-based imaging paradigm of human classical conditioning, we were able to identify dissociable predictive representations of identity-specific reward in orbitofrontal cortex (OFC) and identity-general reward in ventromedial prefrontal cortex (vmPFC). Reward-related functional coupling between OFC and olfactory (piriform) cortex and between vmPFC and amygdala revealed parallel pathways that support identity-specific and -general predictive signaling. The demonstration of identity-specific value representations in OFC highlights a role for this region in model-based behavior and reveals mechanisms by which appetitive behavior can go awry.

Abstract

Nervous systems must encode information about the identity of expected outcomes to make adaptive decisions. However, the neural mechanisms underlying identity-specific value signaling remain poorly understood. By manipulating the value and identity of appetizing food odors in a pattern-based imaging paradigm of human classical conditioning, we were able to identify dissociable predictive representations of identity-specific reward in orbitofrontal cortex (OFC) and identity-general reward in ventromedial prefrontal cortex (vmPFC). Reward-related functional coupling between OFC and olfactory (piriform) cortex and between vmPFC and amygdala revealed parallel pathways that support identity-specific and -general predictive signaling. The demonstration of identity-specific value representations in OFC highlights a role for this region in model-based behavior and reveals mechanisms by which appetitive behavior can go awry.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Language:English
Date:21 April 2015
Deposited On:28 May 2015 07:24
Last Modified:23 Sep 2018 05:52
Publisher:National Academy of Sciences
ISSN:0027-8424
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1073/pnas.1503550112
PubMed ID:25848032
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P1_150739
  • : Project TitleThe neural basis of economic and moral utility
  • : FunderSNSF
  • : Grant IDCRSII3_141965
  • : Project TitleNeuroeconomics of value-based decision making
  • : FunderSNSF
  • : Grant IDPP00P1_128574
  • : Project TitleThe neural basis of economic and moral utility

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