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Increased expression of the proton-sensing G protein-coupled receptor Gpr65 during retinal degeneration

Ail, D; Rüfenacht, V; Caprara, C; Samardzija, M; Kast, B; Grimm, C (2015). Increased expression of the proton-sensing G protein-coupled receptor Gpr65 during retinal degeneration. Neuroscience, 301:496-507.

Abstract

The retina is a metabolically highly active tissue that is sensitive to pH changes. Blinding diseases of the retina are often characterized by degeneration of photoreceptor cells altering the acid-base homeostasis of the tissue microenvironment and by an accompanying inflammatory response. GPR4, GPR65 and GPR68 are G protein-coupled receptors that aid cells to sense and survive conditions of acidic pH and inflammatory cells express Gpr65 enhancing their viability. Hence, we investigated expression and function of these proton-sensing GPRs in the normal and degenerating retina. We observed increased retinal expression of Gpr65, but not of Gpr4 and Gpr68, in mouse models of both inherited (rd10) and induced (light damage) retinal degeneration. Lack of GPR65 slightly accelerated photoreceptor degeneration in rd10 mice and resulted in a strong activation of microglia after light-injury. Since GPR65 was dispensable for normal retinal development, function and aging as evidenced by the evaluation of Gpr65-/- mice, our results indicate that the proton-sensing G protein-coupled receptor GPR65 may be involved in a mechanism that supports survival of photoreceptors in the degenerating retina.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Uncontrolled Keywords:Gpr65, TDAG8, light damage, microglia, rd10, retinal degeneration
Language:English
Date:2015
Deposited On:16 Jul 2015 14:18
Last Modified:13 Oct 2024 01:39
Publisher:Elsevier
ISSN:0306-4522
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.neuroscience.2015.06.039
PubMed ID:26117715
Project Information:
  • Funder: SNSF
  • Grant ID: 31003A_149311
  • Project Title: Blinding Diseases of the Retina: Molecular Signaling and approaches to preserve vision
  • Funder: SNSF
  • Grant ID: 31003A_133043
  • Project Title: Blinding Diseases of the Retina: Molecular Signaling and Neuroprotection

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