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Magnetic stimulation supports muscle and nerve regeneration after trauma in mice

Stölting, Meline N L; Arnold, Anne Sophie; Haralampieva, Deana; Handschin, Christoph; Sulser, Tullio; Eberli, Daniel (2016). Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle & Nerve, 53(4):598-607.

Abstract

INTRODUCTION: Magnetic stimulation (MS) has the ability to induce muscle twitch and has long been proposed as a therapeutic modality for skeletal muscle diseases. However, the molecular mechanisms underlying its means of action have not been defined. METHODS: Muscle regeneration after trauma was studied in a standard muscle injury mouse model. The influence of MS on the formation of motor-units, post-trauma muscle/nerve regeneration, and vascularization was investigated. RESULTS: We found that MS does not cause systemic or muscle damage but improves muscle regeneration by significantly minimizing the presence of inflammatory infiltrate and formation of scars after trauma. It avoids post-trauma muscle atrophy, induces muscle hypertrophy, and increases the metabolism and turnover of muscle. It triples the expression of muscle markers and significantly improves muscle functional recovery after trauma. DISCUSSION: Our results indicate that MS supports muscle and nerve regeneration by activating muscle-nerve cross-talk and inducing the maturation of NMJs.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Health Sciences > Neurology (clinical)
Life Sciences > Cellular and Molecular Neuroscience
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Physiology, Cellular and Molecular Neuroscience, Clinical Neurology
Language:English
Date:2016
Deposited On:29 Oct 2015 11:13
Last Modified:13 Jul 2025 01:38
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0148-639X
Additional Information:This is the peer reviewed version of the following article: Stölting, M.N.L., Arnold, A.S., Haralampieva, D., Handschin, C., Sulser, T. and Eberli, D. (2016), Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle Nerve, 53: 598-607, which has been published in final form at https://doi.org/10.1002/mus.24780. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. (http://www.wileyauthors.com/self-archiving)
OA Status:Green
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/mus.24780
PubMed ID:26202157
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