It is unclear which aspects of the temporomandibular joint (TMJ) anatomy and/or kinematics determine shape and location of disk-compressive areas (stress field). The aim of this study was a quantitative analysis of TMJ anatomy to predict stress field path direction. Twenty-five asymptomatic TMJs (12 females and 13 males, aged 20-38 years) were tracked during unloaded opening/closing cycles. All TMJs were magnetic resonance (MR) imaged, reconstructed and animated with the recorded kinematics. Quantitative morphological parameters were calculated and entered into cross-validated multivariate discriminant analysis. Stress field paths during jaw opening were classified as mediolateral (ML) in 14 (9 females and 5 males) and lateromedial (LM) in 11 joints (3 females and 8 males). Curvature and incongruence as well as the dorsoventral position of the condyle in the fossa showed statistically significant differences (Mann-Whitney U test, p < 0.05). A combination of the lateral incongruence, the distance from the posterior slope of the eminence as well as the maximum posterior sagittal curvature enabled to correctly predict the direction of stress field paths in 92% of cases. In particular, ML type joints had laterally more congruent condyles/fossae and condyles more distant from the posterior slope of the eminence than LM type joints. Within the limits of this study, TMJ morphology seems to determine stress field path patterns.