Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Migration von ZORA auf die Software DSpace

ZORA will change to a new software on 8th September 2025. Please note: deadline for new submissions is 21th July 2025!

Information & dates for training courses can be found here: Information on Software Migration.

Reconstructing cerebrovascular networks under local physiological constraints by integer programming

Rempfler, Markus; Schneider, Matthias; Ielacqua, Giovanna D; Xiao, Xianghui; Stock, Stuart R; Klohs, Jan; Székely, Gábor; Andres, Bjoern; Menze, Bjoern H (2015). Reconstructing cerebrovascular networks under local physiological constraints by integer programming. Medical Image Analysis, 25(1):86-94.

Abstract

We introduce a probabilistic approach to vessel network extraction that enforces physiological constraints on the vessel structure. The method accounts for both image evidence and geometric relationships between vessels by solving an integer program, which is shown to yield the maximum a posteriori (MAP) estimate to a probabilistic model. Starting from an overconnected network, it is pruning vessel stumps and spurious connections by evaluating the local geometry and the global connectivity of the graph. We utilize a high-resolution micro computed tomography (μCT) dataset of a cerebrovascular corrosion cast to obtain a reference network and learn the prior distributions of our probabilistic model and we perform experiments on in-vivo magnetic resonance microangiography (μMRA) images of mouse brains. We finally discuss properties of the networks obtained under different tracking and pruning approaches.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Scopus Subject Areas:Health Sciences > Radiological and Ultrasound Technology
Health Sciences > Radiology, Nuclear Medicine and Imaging
Physical Sciences > Computer Vision and Pattern Recognition
Health Sciences > Health Informatics
Physical Sciences > Computer Graphics and Computer-Aided Design
Language:English
Date:October 2015
Deposited On:19 Nov 2015 11:55
Last Modified:13 Jul 2025 01:39
Publisher:Elsevier
ISSN:1361-8415
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.media.2015.03.008
PubMed ID:25977158
Project Information:
  • Funder: SNSF
  • Grant ID: PZ00P3_136822
  • Project Title: Molecular imaging of neutrophil protease-mediated blood-brain barrier impairment and thrombosis after cerebral ischemia
  • Funder: FP7
  • Grant ID: 291763
  • Project Title: RISKINGCREATIVITY - TUM-IAS Fellowships for the cooperative development of high risk new fields in technology and science
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
17 citations in Web of Science®
22 citations in Scopus®
Google Scholar™

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications