Ruf, Melanie; Moch, Holger; Schraml, Peter (2015). Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma. OncoImmunology, 4(12):e1049805.
CD70 upregulation by hypoxia-inducible factor and CD27(+) lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.
CD70 upregulation by hypoxia-inducible factor and CD27(+) lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Immunology and Allergy
Life Sciences > Immunology Health Sciences > Oncology |
| Language: | English |
| Date: | December 2015 |
| Deposited On: | 26 Nov 2015 11:23 |
| Last Modified: | 26 Jan 2022 07:10 |
| Publisher: | Landes Bioscience |
| ISSN: | 2162-4011 |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1080/2162402X.2015.1049805 |
| PubMed ID: | 26587319 |
Ruf, Melanie