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Perturbing resistance: a network perspective


Levesque, Mitchell P; Dummer, Reinhard; Beerenwinkel, Niko (2015). Perturbing resistance: a network perspective. Pigment Cell & Melanoma Research, 29(1):5-7.

Abstract

The recent convergence of high-dimensional molecular datasets with small-molecule inhibitor pipelines allows for selective targeting of aberrantly regulated pathways in many cancer types. But intra-tumor heterogeneity, paradoxical activation, intrinsic or acquired therapeutic resistance, and non-linear pathway interactions confound most simple targeting strategies(Widmer et al., 2015). For instance, MAPK signaling is activated by hot-spot mutations in BRAF, which are found in about 40-50% of melanoma cases. This article is protected by copyright. All rights reserved.

Abstract

The recent convergence of high-dimensional molecular datasets with small-molecule inhibitor pipelines allows for selective targeting of aberrantly regulated pathways in many cancer types. But intra-tumor heterogeneity, paradoxical activation, intrinsic or acquired therapeutic resistance, and non-linear pathway interactions confound most simple targeting strategies(Widmer et al., 2015). For instance, MAPK signaling is activated by hot-spot mutations in BRAF, which are found in about 40-50% of melanoma cases. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Health Sciences > Dermatology
Language:English
Date:16 October 2015
Deposited On:21 Dec 2015 13:49
Last Modified:13 May 2020 20:42
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1755-1471
Additional Information:News and Views; This is the peer reviewed version of the following article: [evesque, M. P., Dummer, R. and Beerenwinkel, N. (2016), Perturbing resistance: a network perspective. Pigment Cell & Melanoma Research, 29: 5–7. doi: 10.1111/pcmr.12431], which has been published in final form at [http://doi.org/10.1111/pcmr.12431]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
OA Status:Green
Publisher DOI:https://doi.org/10.1111/pcmr.12431
PubMed ID:26471867

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