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vWF fibers induce thrombosis during cancer


Borsig, Lubor (2015). vWF fibers induce thrombosis during cancer. Blood, 125(20):3042-3043.

Abstract

In this issue of Blood, Bauer et al1 provide an explanation for the formation of luminal von Willebrand factor (vWF) fibers observed in cancer patients, which is initiated through tumor-derived VEGF-A. Platelet aggregation on vWF fibers correlated with a prothrombic state associated with decreased ADAMTS13 activity in cancer patients.

Abstract

In this issue of Blood, Bauer et al1 provide an explanation for the formation of luminal von Willebrand factor (vWF) fibers observed in cancer patients, which is initiated through tumor-derived VEGF-A. Platelet aggregation on vWF fibers correlated with a prothrombic state associated with decreased ADAMTS13 activity in cancer patients.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Biochemistry
Life Sciences > Immunology
Health Sciences > Hematology
Life Sciences > Cell Biology
Language:English
Date:14 May 2015
Deposited On:07 Jan 2016 11:23
Last Modified:26 Mar 2020 00:42
Publisher:American Society of Hematology
ISSN:0006-4971
Additional Information:This research was originally published in Blood. Borsig, Lubor (2015). vWF fibers induce thrombosis during cancer. Blood, 125(20):3042-3043. Copyright by the American Society of Hematology.
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1182/blood-2015-03-632141
PubMed ID:25977579

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