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From TcVIIto TcI; facile syntheses of bis-arene complexes [99(m)Tc(arene)2]+from pertechnetate


Benz, Michael; Braband, Henrik; Schmutz, Paul; Halter, Jonathan; Alberto, Roger (2015). From TcVIIto TcI; facile syntheses of bis-arene complexes [99(m)Tc(arene)2]+from pertechnetate. Chemical Science, 6(1):165-169.

Abstract

Bis-arene complexes of technetium represent a fundamental class of organometallic compounds. Due to complex synthetic routes, no detailed insights into their properties have been reported so far. Reacting [99TcO4]- with arenes in the exclusive presence of AlCl3 gives highly stable [99Tc(arene)2]+ in good yields. These complexes have extraordinarily high stabilities, where oxidation is found to occur at potentials higher than +1.3 V and reduction at potentials below -2Vvs. Fc/Fc+. The 99mTc analogues are similarly synthesised by applying a novel ionic liquid extraction pathway. Complexes of 99mTc with suitably functionalized arenes will represent new building blocks for bioorganometallic pharmaceuticals in molecular imaging.

Abstract

Bis-arene complexes of technetium represent a fundamental class of organometallic compounds. Due to complex synthetic routes, no detailed insights into their properties have been reported so far. Reacting [99TcO4]- with arenes in the exclusive presence of AlCl3 gives highly stable [99Tc(arene)2]+ in good yields. These complexes have extraordinarily high stabilities, where oxidation is found to occur at potentials higher than +1.3 V and reduction at potentials below -2Vvs. Fc/Fc+. The 99mTc analogues are similarly synthesised by applying a novel ionic liquid extraction pathway. Complexes of 99mTc with suitably functionalized arenes will represent new building blocks for bioorganometallic pharmaceuticals in molecular imaging.

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Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > General Chemistry
Language:English
Date:5 September 2015
Deposited On:14 Jan 2016 09:34
Last Modified:01 Apr 2020 21:05
Publisher:Royal Society of Chemistry
ISSN:2041-6520
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1039/c4sc02461c
Official URL:http://pubs.rsc.org/en/content/articlepdf/2015/sc/c4sc02461c?page=search

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