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miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth

Carrella, Sabrina; D'Agostino, Ylenia; Barbato, Sara; Huber-Reggi, Sabina P; Salierno, Francesco G; Manfredi, Anna; Neuhauss, Stephan C F; Banfi, Sandro; Conte, Ivan (2015). miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth. Developmental Neurobiology, 75(11):1252-1267.

Abstract

Connectivity and function of neuronal circuitry require the correct specification and growth of axons and dendrites. Here, we identify the microRNAs miR-181a and miR-181b as key regulators of retinal axon specification and growth. Loss of miR-181a/b in medaka fish (Oryzias latipes) failed to consolidate amacrine cell processes into axons and delayed the growth of retinal ganglion cell (RGC) axons. These alterations were accompanied by defects in visual connectivity and function. We demonstrated that miR-181a/b exert these actions through negative modulation of MAPK/ERK signaling that in turn leads to RhoA reduction and proper neuritogenesis in both amacrine cells and RGCs via local cytoskeletal rearrangement. Our results identify a new pathway for axon specification and growth unraveling a crucial role of miR-181a/b in the proper establishment of visual system connectivity and function.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Developmental Neuroscience
Life Sciences > Cellular and Molecular Neuroscience
Language:English
Date:November 2015
Deposited On:13 Jan 2016 15:38
Last Modified:14 Jul 2025 01:36
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1932-8451
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/dneu.22282
PubMed ID:25728313
Project Information:
  • Funder: SNSF
  • Grant ID: 31003A_135598
  • Project Title: Genetic Analysis of Vertebrate Vision
  • Funder: FP7
  • Grant ID: 242048
  • Project Title: ZF-HEALTH - Zebrafish Regulomics for Human Health
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