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Recent strategies and progress in identifying host factors involved in virus replication


König, R; Stertz, S (2015). Recent strategies and progress in identifying host factors involved in virus replication. Current Opinion in Microbiology, (26):79-88.

Abstract

Viruses are completely dependent on their host cells for the successful production of progeny viruses. At each stage of the viral life cycle an intricate interplay between virus and host takes place with the virus aiming to usurp the host cell for its purposes and the host cell trying to block the intruder from propagation. In recent years these interactions have been studied on a global level by systems biology approaches, such as RNA interference screens, transcriptomic or proteomic methodologies, and exciting new insights into the pathogen–host relationship have been revealed. In this review, we summarize the available data, give examples for important findings from such studies and point out current limitations and potential future directions.

Abstract

Viruses are completely dependent on their host cells for the successful production of progeny viruses. At each stage of the viral life cycle an intricate interplay between virus and host takes place with the virus aiming to usurp the host cell for its purposes and the host cell trying to block the intruder from propagation. In recent years these interactions have been studied on a global level by systems biology approaches, such as RNA interference screens, transcriptomic or proteomic methodologies, and exciting new insights into the pathogen–host relationship have been revealed. In this review, we summarize the available data, give examples for important findings from such studies and point out current limitations and potential future directions.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:Microbiology (medical), Microbiology, Infectious Diseases
Language:English
Date:23 June 2015
Deposited On:15 Feb 2016 15:24
Last Modified:19 Aug 2018 01:23
Publisher:Elsevier
ISSN:1369-5274
Funders:Swiss National Science Foundation (31003A_156805), Novartis Research Foundation, German Center for Infection Research (DZIF)
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.mib.2015.06.001
Official URL:http://ac.els-cdn.com/S136952741500065X/1-s2.0-S136952741500065X-main.pdf?_tid=f2a00bd0-bad5-11e5-83c2-00000aacb362&acdnat=1452786556_7a2b76648ccd19511315b3cbc8f7f9d0
PubMed ID:26112615
Project Information:
  • : FunderSNSF
  • : Grant ID
  • : Project TitleSwiss National Science Foundation (31003A_156805)
  • : Funder
  • : Grant ID
  • : Project TitleNovartis Research Foundation
  • : Funder
  • : Grant ID
  • : Project TitleGerman Center for Infection Research (DZIF)

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