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Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence

Matteucci, Marco; Papini, Gaia; Ciofini, Enrica; Barile, Lucio; Lionetti, Vincenzo (2015). Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence. Current Drug Targets, 16(8):827-842.

Abstract

The adult myocardium has limited capacity to preserve, renew or rejuvenate itself. The local microenvironment may induce epigenetic changes affecting the survival, proliferation, function and senescence of cardiac cells at rest and following the exposure to different stressors. The cellular response to microenvironment is characterized by the release of ions, oxygen free radicals, auto/paracrine factors and RNAs that drive the magnitude of gene reprogramming through the interaction with specific promoters. The epigenetic alterations may act at transcriptional and post-transcriptional level and change cardiac physiological traits. The abnormal DNA methylation underlies the progressive decay of contractile function and the angiogenic ability; while, the histone acetylation promotes the survival, function and proliferation of cardiac cells in the presence of ischemic microenvironment. At least, the expression and secretion of microRNAs and long noncoding RNAs may regulate the threshold to stress tolerance of adult cardiac cells and induce the matrix turnover as well. Natural or synthetic active compounds effectively modulate the epigenetic state of cardiac cells. Plant foods contain many active compounds with epigenetic properties and might assume a clinical significance as natural cardiac regenerators or rejuvenators. Our review describes novel epigenetic mechanisms that underpin myocardial remodeling, repair/ regeneration or senescence in order to support the development of most effective and reproducible rescue therapy of adult heart.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Cardiocentro Ticino
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Medicine
Life Sciences > Pharmacology
Life Sciences > Drug Discovery
Life Sciences > Clinical Biochemistry
Language:English
Date:2015
Deposited On:01 Feb 2016 12:48
Last Modified:14 Nov 2024 02:38
Publisher:Bentham Science Publishers Ltd.
ISSN:1389-4501
OA Status:Closed
Publisher DOI:https://doi.org/10.2174/1389450116666150630110821
PubMed ID:26122032

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