Ongoing (2014–15) drought in the state of California has played a major role in the depletion of groundwater. Within California’s Central Valley, home to one of the world’s most productive agricultural regions, drought and increased groundwater depletion occurs almost hand in hand, but this relationship appears to have changed over the last decade. Data derived from 497 wells have revealed a continued depletion of groundwater lasting a full year after drought, a phenomenon that was not observed in earlier records before the twenty-first century. Possible causes include 1) lengthening of drought associated with amplification in the 4–6-yr drought frequency since the late 1990s and 2) intensification of drought and increased pumping that enhances depletion. Altogether, the implication is that groundwater storage in the Central Valley will likely continue to diminish even further in 2016, regardless of the drought status.