Abstract
Inflammation is the natural reaction of the body toward tissue injury or pathogen invasion with the ultimate goal to restore homeostasis. When tissue resident APCs sense a perturbation, they release an array of chemokines and signalling molecules, which in turn attract further leukocytes into the affected tissue. Neutrophils, highly specialized microbial killers, are the first cells attracted from the blood stream to counter the noxious agents. In second place, the activated environment also promotes the development of classically activated M1 macrophages in the tissue, which work in concomitance with neutropihls and sustain the inflammatory reaction.
Schmid, Mattia