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Organ chips: quality assurance systems in regenerative medicine


Pasqualini, Francesco S; Emmert, Maximillian Y; Parker, Kevin Kit; Hoerstrup, Simon P (2017). Organ chips: quality assurance systems in regenerative medicine. Clinical Pharmacology and Therapeutics, 101(1):31-34.

Abstract

A class of novel therapies leverages regenerative cell types in disease microenvironments. This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. That is, we can build the product right, but we do not know if we are building the right product. Here, we suggest that organ‐chips, biomimetic in vitro phenotyping platforms, can serve as key quality assurance systems in regenerative medicine.

Abstract

A class of novel therapies leverages regenerative cell types in disease microenvironments. This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. That is, we can build the product right, but we do not know if we are building the right product. Here, we suggest that organ‐chips, biomimetic in vitro phenotyping platforms, can serve as key quality assurance systems in regenerative medicine.

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5 citations in Web of Science®
3 citations in Scopus®
2 citations in Microsoft Academic
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:6 October 2017
Deposited On:19 Mar 2018 18:32
Last Modified:30 Jan 2020 07:34
Publisher:Nature Publishing Group
ISSN:0009-9236
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/cpt.527
PubMed ID:27709615

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