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Asquith, Christopher R M; Konstantinova, Lidia S; Laitinen, Tuomo; Meli, Marina L; Poso, Antti; Rakitin, Oleg A; Hofmann-Lehmann, Regina; Hilton, Stephen T (2016). Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism. ChemMedChem, 11(19):2119-2126.
A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
05 Vetsuisse Faculty > Center for Clinical Studies |
| Dewey Decimal Classification: | 570 Life sciences; biology
630 Agriculture |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Pharmacology Life Sciences > Drug Discovery Life Sciences > General Pharmacology, Toxicology and Pharmaceutics Physical Sciences > Organic Chemistry |
| Uncontrolled Keywords: | FIV, HIV-1, homology models, nucleocapsid protein, zinc abstraction, zinc ejection |
| Language: | English |
| Date: | 6 October 2016 |
| Deposited On: | 28 Nov 2016 10:54 |
| Last Modified: | 12 Feb 2025 04:43 |
| Publisher: | Wiley-Blackwell Publishing, Inc. |
| ISSN: | 1860-7179 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/cmdc.201600260 |
| PubMed ID: | 27511289 |
Asquith, Christopher R M