The current study investigated the use of selection, optimization, and compensation (SOC) in association with momentary goal conflict and facilitation in middle adulthood. In contrast to previous studies on SOC that focused on the habitual use of the SOC-strategies, the current study investigated the momentary SOC-use in the everyday lives of adults who face the developmental challenge of combining the demands of multiple life domains (e.g., work, family, leisure). In a sample of N = 89 employed middle-age adults, momentary SOC-use as well as momentary goal conflict and facilitation were assessed in a measurement burst design encompassing 20 days (M = 126 measurement points per person). Time-lagged analyses showed that momentary goal conflict was positively related to subsequent optimization and compensation, and momentary goal facilitation lead to lower subsequent loss-based selection and compensation. In contrast, SOC predicted neither subsequent goal conflict nor facilitation. Thus, the use of SOC-strategies seems to be a response to – rather than an antecedent of - currently experienced goal relations (conflict, facilitation), underscoring the importance of these strategies for managing multiple goals.