Header

UZH-Logo

Maintenance Infos

Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions


Chiotellis, Aristeidis; Sladojevich, Filippo; Mu, Linjing; Müller Herde, Adrienne; Valverde, Ibai E; Tolmachev, Vladimir; Schibli, Roger; Ametamey, Simon M; Mindt, Thomas L (2016). Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions. Chemical Communications, 52(36):6083-6086.

Abstract

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Abstract

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Statistics

Citations

Dimensions.ai Metrics
22 citations in Web of Science®
23 citations in Scopus®
8 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 05 Dec 2016
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials
Physical Sciences > Ceramics and Composites
Physical Sciences > General Chemistry
Physical Sciences > Surfaces, Coatings and Films
Physical Sciences > Metals and Alloys
Physical Sciences > Materials Chemistry
Language:English
Date:4 May 2016
Deposited On:05 Dec 2016 14:10
Last Modified:29 Apr 2020 22:25
Publisher:Royal Society of Chemistry
ISSN:1359-7345
OA Status:Closed
Publisher DOI:https://doi.org/10.1039/c6cc01982j
PubMed ID:27043419

Download

Closed Access: Download allowed only for UZH members