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Chiotellis, Aristeidis; Sladojevich, Filippo; Mu, Linjing; Müller Herde, Adrienne; Valverde, Ibai E; Tolmachev, Vladimir; Schibli, Roger; Ametamey, Simon M; Mindt, Thomas L (2016). Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions. Chemical Communications, 52(36):6083-6086.
We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials Physical Sciences > Ceramics and Composites Physical Sciences > General Chemistry Physical Sciences > Surfaces, Coatings and Films Physical Sciences > Metals and Alloys Physical Sciences > Materials Chemistry |
| Language: | English |
| Date: | 4 May 2016 |
| Deposited On: | 05 Dec 2016 14:10 |
| Last Modified: | 14 Apr 2025 01:39 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1039/c6cc01982j |
| PubMed ID: | 27043419 |
Chiotellis, Aristeidis