Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

DDOS: due to massive botnet requests against our ‘Advanced Search’ we have restricted access to UZH (local and VPN). Thank you for your understanding.

Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV

Ferrantelli, Flavia; Rasmussen, Robert A; Hofmann-Lehmann, Regina; Xu, Weidong; McClure, Harold M; Ruprecht, Ruth M (2002). Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV. Vaccine, 20(Suppl 4):A61-A65.

Abstract

Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prevented infection in primates, indicating that epitopes recognized by such nmAbs are key determinants for protection. Lastly, in the absence of CD8+ T cells, nAbs may act as a second line of defense during chronic infection. Taken together, these results argue for generating nAb response-based prophylactic and/or therapeutic AIDS vaccines. We suggest that the epitopes identified by passive immunization represent excellent targets for the rational design of nAb response-based AIDS vaccines.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Life Sciences > Molecular Medicine
Life Sciences > General Immunology and Microbiology
Health Sciences > General Veterinary
Health Sciences > Public Health, Environmental and Occupational Health
Health Sciences > Infectious Diseases
Language:English
Date:19 December 2002
Deposited On:30 Nov 2016 13:31
Last Modified:14 Jun 2025 01:40
Publisher:Elsevier
ISSN:0264-410X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/S0264-410X(02)00389-4
PubMed ID:12477430

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
26 citations in Web of Science®
32 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 30 Nov 2016
0 downloads since 12 months

Authors, Affiliations, Collaborations

Similar Publications