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Bile acids in drug induced liver injury: Key players and surrogate markers


Schadt, Heiko S; Wolf, Armin; Pognan, Francois; Chibout, Salah-Dine; Merz, Michael; Kullak-Ublick, Gerd A (2016). Bile acids in drug induced liver injury: Key players and surrogate markers. Clinics and Research in Hepatology and Gastroenterology, 40(3):257-266.

Abstract

Bile acid research has gained great momentum since the role of bile acids as key signaling molecules in the enterohepatic circulation was discovered. Their physiological function in regulating their own homeostasis, as well as energy and lipid metabolism make them interesting targets for the pharmaceutical industry in the context of diseases such as bile acid induced diarrhea, bile acid induced cholestasis or nonalcoholic steatohepatitis. Changes in bile acid homeostasis are also linked to various types of drug-induced liver injury (DILI). However, the key question whether bile acids are surrogate markers for monitoring DILI or key pathogenic players in the onset and progression of DILI is under intense investigation. The purpose of this review is to summarize the different facets of bile acids in the context of normal physiology, hereditary defects of bile acid transport and DILI.

Abstract

Bile acid research has gained great momentum since the role of bile acids as key signaling molecules in the enterohepatic circulation was discovered. Their physiological function in regulating their own homeostasis, as well as energy and lipid metabolism make them interesting targets for the pharmaceutical industry in the context of diseases such as bile acid induced diarrhea, bile acid induced cholestasis or nonalcoholic steatohepatitis. Changes in bile acid homeostasis are also linked to various types of drug-induced liver injury (DILI). However, the key question whether bile acids are surrogate markers for monitoring DILI or key pathogenic players in the onset and progression of DILI is under intense investigation. The purpose of this review is to summarize the different facets of bile acids in the context of normal physiology, hereditary defects of bile acid transport and DILI.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Gastroenterology
Language:English
Date:2016
Deposited On:08 Dec 2016 13:30
Last Modified:19 Aug 2018 05:26
Publisher:Elsevier
ISSN:2210-7401
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.clinre.2015.12.017
PubMed ID:26874804

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