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Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver


Gerspach, Christian; Ruetten, Maja; Riond, Barbara (2016). Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver. Schweizer Archiv für Tierheilkunde, 158(12):811-818.

Abstract

The aim of the present study was to investigate clotting profiles, plasma biochemical, and hematological parameters in cows with different degrees of fatty liver. The degree of fatty liver was determined based on histopathology of liver biopsies. Fifty cows referred for left displacement of the abomasum and different degrees of fatty liver were investigated. A clotting profile including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (aPTT), and fibrinogen did not reveal differences between cows with or without fatty liver. Aspartate aminotransferase (ASAT) was the only biochemical parameter being significantly different in cows with fatty liver. The activity of ASAT could not differentiate any stage of fatty liver. Our findings demonstrate that alterations in clotting profiles in dairy cows are not related to fatty liver. Biochemical parameters are not sufficient to determine the severity of fatty liver.

Abstract

The aim of the present study was to investigate clotting profiles, plasma biochemical, and hematological parameters in cows with different degrees of fatty liver. The degree of fatty liver was determined based on histopathology of liver biopsies. Fifty cows referred for left displacement of the abomasum and different degrees of fatty liver were investigated. A clotting profile including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (aPTT), and fibrinogen did not reveal differences between cows with or without fatty liver. Aspartate aminotransferase (ASAT) was the only biochemical parameter being significantly different in cows with fatty liver. The activity of ASAT could not differentiate any stage of fatty liver. Our findings demonstrate that alterations in clotting profiles in dairy cows are not related to fatty liver. Biochemical parameters are not sufficient to determine the severity of fatty liver.

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Additional indexing

Other titles:Untersuchung von Gerinnungsprofilen und biochemischen Parametern bei Milchkühen mit unterschiedlichen Schweregraden der Leberverfettung
Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:cattle, fatty liver, coagulation, liver, ketosis
Language:English
Date:December 2016
Deposited On:13 Jan 2017 08:53
Last Modified:02 Feb 2018 11:33
Publisher:Gesellschaft Schweizer Tierärztinnen und Tierärzte
ISSN:0036-7281
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.17236/sat00096
PubMed ID:27934623

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