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Photodynamic endometrial ablation for the treatment of dysfunctional uterine bleeding: a preliminary report


Degen Iseli, Andrea Franziska; Gabrecht, Tanja; Mosimann, Laurent; Fehr, Mathias K; Hornung, René; Schwarz, Viola A; Tadir, Yona; Steiner, Rolf A; Wagnières, Georges; Wyss, Pius (2004). Photodynamic endometrial ablation for the treatment of dysfunctional uterine bleeding: a preliminary report. Lasers in surgery and medicine, 34(1):1-4.

Abstract

BACKGROUND AND OBJECTIVES To evaluate feasibility and functional effects of photodynamic endometrial ablation (PEA) in patients.
STUDY DESIGN/PATIENTS AND METHODS A total of 15 PEAs has been performed in 11 patients using topically applied 5-aminolevulinic acid (ALA) solutions and a balloon-light diffuser (160 J/cm(2), 635 nm). Uterine bleeding intensity has been determined on a daily basis 3 months prior to and up to 6 months after endometrial ablation using an analogous scale scoring from 1 (spotting) to 6 U (severe bleeding). Statistical analysis by unpaired Student's t-test.
RESULTS The mean number of bleeding units per cycle (n = 44) was 35.7 prior to PEA. The decrease in bleeding units was significant for the months 1-3 (24.4 U per cycle; P = 0.03), but not for the months 4-6 (25.9 U; P = 0.11) following PEA.
CONCLUSIONS PEA is feasible and provides a significant short-term reduction of uterine bleeding.

Abstract

BACKGROUND AND OBJECTIVES To evaluate feasibility and functional effects of photodynamic endometrial ablation (PEA) in patients.
STUDY DESIGN/PATIENTS AND METHODS A total of 15 PEAs has been performed in 11 patients using topically applied 5-aminolevulinic acid (ALA) solutions and a balloon-light diffuser (160 J/cm(2), 635 nm). Uterine bleeding intensity has been determined on a daily basis 3 months prior to and up to 6 months after endometrial ablation using an analogous scale scoring from 1 (spotting) to 6 U (severe bleeding). Statistical analysis by unpaired Student's t-test.
RESULTS The mean number of bleeding units per cycle (n = 44) was 35.7 prior to PEA. The decrease in bleeding units was significant for the months 1-3 (24.4 U per cycle; P = 0.03), but not for the months 4-6 (25.9 U; P = 0.11) following PEA.
CONCLUSIONS PEA is feasible and provides a significant short-term reduction of uterine bleeding.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
Dewey Decimal Classification:340 Law
Scopus Subject Areas:Health Sciences > Surgery
Health Sciences > Dermatology
Language:English
Date:2004
Deposited On:30 Jan 2017 10:13
Last Modified:19 Nov 2023 08:04
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0196-8092
Funders:KTI
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/lsm.10244
PubMed ID:14755418