Abstract
The objective of this chapter is to summarize the criticisms of laboratory friction protocols that appeared in the last two decades through a critique of the research protocols employed, assessment of the clinical relevance of the results reported, and analysis of the main factors. From this summary, use of the in vitro approach is precluded as a reliable method for clarification of the impact of research findings at the clinical level. To this end, an analysis of the methodological approaches employed for the investigation of frictional effects during bracket sliding on wires raises a number of issues.