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Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes

von Hof, Jessica; Sprekeler, Nele; Schuler, Gerhard; Boos, Alois; Kowalewski, Mariusz P (2016). Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes. Prostaglandins & Other Lipid Mediators, 128-129:17-26.

Abstract

15-Hydroxyprostaglandin dehydrogenase (HPGD) plays a key role in prostaglandins (PGs) catabolism. Its expression and activity appear to be regulated by progesterone (P4). We investigated the HPGD mRNA-expression and protein localization in placentomes and interplacental uterine sites throughout gestation (Study I), and after fetal membranes retention (RFM) compared with normally delivered fetal membranes (DFM) (Study II). Furthermore, we analyzed the influence of aglepristone (AP), dexamethasone (GC) or cloprostenol (CP), on HPGD expression in bovine placentomes (Study III). Tissues from late gestation (D272) and at normal term (NT) served as controls. HPGD was highest in all sites at the beginning of pregnancy and at (NT). Following induced parturition HPGD was lower after (AP) and (GC) compared with (NT), and was similar in RFM and DFM. Placentomes stained primarily in fetal compartments; interplacentomal signals were observed in endometrial glandular and luminal epithelium. Results indicate that HPGD may play a role during establishment and termination of gestation.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Veterinary Anatomy
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Biochemistry
Life Sciences > Physiology
Life Sciences > Pharmacology
Life Sciences > Cell Biology
Uncontrolled Keywords:Bovine, Cattle, Gestation, HPGD, Placenta, Retained fetal membranes, Uterus
Language:English
Date:30 December 2016
Deposited On:09 Feb 2017 13:27
Last Modified:15 Jun 2025 01:39
Publisher:Elsevier
ISSN:1098-8823
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.prostaglandins.2016.12.003
PubMed ID:28043888
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