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The cerebellar mossy fiber synapse as a model for high-frequency transmission in the mammalian CNS


Delvendahl, Igor; Hallermann, Stefan (2016). The cerebellar mossy fiber synapse as a model for high-frequency transmission in the mammalian CNS. Trends in Neurosciences, 39(11):722-737.

Abstract

The speed of neuronal information processing depends on neuronal firing frequency. Here, we describe the evolutionary advantages and ubiquitous occurrence of high-frequency firing within the mammalian nervous system in general. The highest firing frequencies so far have been observed at the cerebellar mossy fiber to granule cell synapse. The mechanisms enabling high-frequency transmission at this synapse are reviewed and compared with other synapses. Finally, information coding of high-frequency signals at the mossy fiber synapse is discussed. The exceptionally high firing frequencies and amenability to high-resolution technical approaches both in vitro and in vivo establish the cerebellar mossy fiber synapse as an attractive model to investigate high-frequency signaling from the molecular up to the network level.

Abstract

The speed of neuronal information processing depends on neuronal firing frequency. Here, we describe the evolutionary advantages and ubiquitous occurrence of high-frequency firing within the mammalian nervous system in general. The highest firing frequencies so far have been observed at the cerebellar mossy fiber to granule cell synapse. The mechanisms enabling high-frequency transmission at this synapse are reviewed and compared with other synapses. Finally, information coding of high-frequency signals at the mossy fiber synapse is discussed. The exceptionally high firing frequencies and amenability to high-resolution technical approaches both in vitro and in vivo establish the cerebellar mossy fiber synapse as an attractive model to investigate high-frequency signaling from the molecular up to the network level.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:General Neuroscience
Language:English
Date:November 2016
Deposited On:13 Feb 2017 12:53
Last Modified:19 Aug 2018 08:23
Publisher:Elsevier
ISSN:0166-2236
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.tins.2016.09.006
Related URLs:http://www.cell.com/trends/neurosciences/fulltext/S0166-2236%2816%2930117-5
PubMed ID:27771145

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