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Role of MRI in diagnosis and management of idiopathic inflammatory myopathies


Maurer, Britta; Walker, Ulrich A (2015). Role of MRI in diagnosis and management of idiopathic inflammatory myopathies. Current Rheumatology Reports, 17(11):67.

Abstract

The idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of muscle diseases. Given their potential amenability to immunosuppressive treatment, the early diagnosis of the IIM subtype and the exclusion of "myositis mimics" are of great importance. MRI can visualize muscle edema, fatty replacement, atrophy, subcutaneous pathology, and fasciitis. MRI furthermore provides information about the distribution of muscle involvement and help in guiding of muscle biopsy. This review discusses significant MRI developments aimed at improving the diagnostic sensitivity and specificity, and at assessing IIM activity and damage. The manuscript also highlights techniques such as magnetic resonance spectroscopy, blood oxygenation level-dependent MRI, and diffusion-weighted MRI and T2 mapping which may in the future allow to better characterize vascular involvement, metabolic reserves, dynamic muscle recruitment, and treatment outcome.

Abstract

The idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of muscle diseases. Given their potential amenability to immunosuppressive treatment, the early diagnosis of the IIM subtype and the exclusion of "myositis mimics" are of great importance. MRI can visualize muscle edema, fatty replacement, atrophy, subcutaneous pathology, and fasciitis. MRI furthermore provides information about the distribution of muscle involvement and help in guiding of muscle biopsy. This review discusses significant MRI developments aimed at improving the diagnostic sensitivity and specificity, and at assessing IIM activity and damage. The manuscript also highlights techniques such as magnetic resonance spectroscopy, blood oxygenation level-dependent MRI, and diffusion-weighted MRI and T2 mapping which may in the future allow to better characterize vascular involvement, metabolic reserves, dynamic muscle recruitment, and treatment outcome.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:November 2015
Deposited On:28 Mar 2017 12:40
Last Modified:14 Feb 2018 11:33
Publisher:Springer
ISSN:1523-3774
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s11926-015-0544-x
PubMed ID:26385754

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