Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

The role of perforin in infections and tumour surveillance

van den Broek, M F; Hengartner, H (2000). The role of perforin in infections and tumour surveillance. Experimental Physiology, 85(6):681-685.

Abstract

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are able to lyse suitable target cells. CTLs recognize a specific peptide epitope presented by major histocompatibility complex (MHC) class I molecules on the target cells, whereas NK cells lyse targets that express no or low MHC class I molecules. Using perforin-deficient mice, we provide evidence that both NK cells and CTLs exclusively use perforin-dependent cytolysis as an effector mechanism in vitro, as well as in vivo. This review summarizes the most important role of perforin-dependent cytolysis in a wide variety of bacterial and viral infections, in tumour surveillance, in immunopathology and in autoimmunity.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Health Sciences > Nutrition and Dietetics
Health Sciences > Physiology (medical)
Language:English
Date:November 2000
Deposited On:08 Feb 2018 15:32
Last Modified:17 Oct 2024 01:36
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0958-0670
OA Status:Closed
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/j.1469-445X.2000.02097.x
PubMed ID:11187963
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
34 citations in Web of Science®
35 citations in Scopus®
Google Scholar™

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications