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Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment


Leung, R K; Thomson, K; Gallimore, A; Jones, E; Van den Broek, M; Sierro, S; Alsheikhly, A R; McMichael, A; Rahemtulla, A (2001). Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nature Immunology, 2(12):1167-1173.

Abstract

The mechanism of T cell lineage commitment remains controversial; to examine it we deleted the CD4-silencer element in the germ line of a mouse using a combination of gene targeting and Cre/LoxP-mediated recombination. We found that these mice were unable to extinguish CD4 expression either in immature thymocytes or mature CD8+ cytotoxic T cells (CTLs), which resulted in the development of major histocompatibility complex class II-restricted double-positive CTLs in the periphery. This finding strongly supports a stochastic over an instructive mechanism of coreceptor down-regulation.

Abstract

The mechanism of T cell lineage commitment remains controversial; to examine it we deleted the CD4-silencer element in the germ line of a mouse using a combination of gene targeting and Cre/LoxP-mediated recombination. We found that these mice were unable to extinguish CD4 expression either in immature thymocytes or mature CD8+ cytotoxic T cells (CTLs), which resulted in the development of major histocompatibility complex class II-restricted double-positive CTLs in the periphery. This finding strongly supports a stochastic over an instructive mechanism of coreceptor down-regulation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:December 2001
Deposited On:08 Feb 2018 15:34
Last Modified:19 Feb 2018 22:10
Publisher:Nature Publishing Group
ISSN:1529-2908
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/ni733
PubMed ID:11694883

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