To clarify the order parameter symmetry of cuprates, the magnetic penetration depth λ was measured along the crystallographic directions a, b, and c in single crystals of YBa2Cu4O8 via muon spin rotation. This method is direct, bulk sensitive, and unambiguous. The temperature dependences of λ a −2 and λ b −2 exhibit an inflection point at low temperatures as is typical for two-gap superconductivity (TGS) with s+d-wave character in the planes. Perpendicular to the planes a pure s-wave gap is observed thereby highlighting the important role of c-axis effects. We conclude that these are generic and universal features in the bulk of cuprates.