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New linear polyamine derivatives in spider venoms


Tzouros, Manuel; Chesnov, Sergiy; Bienz, Stefan; Hesse, Manfred; Bigler, Laurent (2005). New linear polyamine derivatives in spider venoms. Toxicon, 46(3):350-354.

Abstract

Linear free polyamines were characterized in the venom of the spiders Agelenopsis aperta, Hololena curta, and Paracoelotes
birulai by RP-HPLC coupled to mass spectrometry. The several linear polyamines found were tetramine, pentamine, and
hexamine derivatives. Some of these natural products were identified as N-hydroxylated, guanidylated, or acetylated
compounds. In addition, the biosynthetical pathway leading to the formation of acylpolyamines in spider venoms is discussed.

Abstract

Linear free polyamines were characterized in the venom of the spiders Agelenopsis aperta, Hololena curta, and Paracoelotes
birulai by RP-HPLC coupled to mass spectrometry. The several linear polyamines found were tetramine, pentamine, and
hexamine derivatives. Some of these natural products were identified as N-hydroxylated, guanidylated, or acetylated
compounds. In addition, the biosynthetical pathway leading to the formation of acylpolyamines in spider venoms is discussed.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:Spider toxins, APCI, MS/MS, Triple quadrupole, Gas-phase fragmentation
Language:English
Date:2005
Deposited On:24 Aug 2017 14:42
Last Modified:19 Feb 2018 20:15
Publisher:Elsevier
ISSN:0041-0101
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.toxicon.2005.04.018
PubMed ID:15982700

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