Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Neuroanatomical and resting state EEG power correlates of central hearing loss in older adults

Giroud, Nathalie; Hirsiger, Sarah; Muri, Raphaela; Kegel, Andrea; Dillier, Norbert; Meyer, Martin (2018). Neuroanatomical and resting state EEG power correlates of central hearing loss in older adults. Brain Structure & Function, 223(1):145-163.

Abstract

To gain more insight into central hearing loss, we investigated the relationship between cortical thickness and surface area, speech-relevant resting state EEG power, and above-threshold auditory measures in older adults and younger controls. Twenty-three older adults and 13 younger controls were tested with an adaptive auditory test battery to measure not only traditional pure-tone thresholds, but also above individual thresholds of temporal and spectral processing. The participants’ speech recognition in noise (SiN) was evaluated, and a T1-weighted MRI image obtained for each participant. We then determined the cortical thickness (CT) and mean cortical surface area (CSA) of auditory and higher speech-relevant regions of interest (ROIs) with FreeSurfer. Further, we obtained resting state EEG from all participants as well as data on the intrinsic theta and gamma power lateralization, the latter in accordance with predictions of the Asymmetric Sampling in Time hypothesis regarding speech processing (Poeppel, Speech Commun 41:245–255, 2003). Methodological steps involved the calculation of age-related differences in behavior, anatomy and EEG power lateralization, followed by multiple regressions with anatomical ROIs as predictors for auditory performance. We then determined anatomical regressors for theta and gamma lateralization, and further constructed all regressions to investigate age as a moderator variable. Behavioral results indicated that older adults performed worse in temporal and spectral auditory tasks, and in SiN, despite having normal peripheral hearing as signaled by the audiogram. These behavioral age-related distinctions were accompanied by lower CT in all ROIs, while CSA was not different between the two age groups. Age modulated the regressions specifically in right auditory areas, where a thicker cortex was associated with better auditory performance in older adults. Moreover, a thicker right supratemporal sulcus predicted more rightward theta lateralization, indicating the functional relevance of the right auditory areas in older adults. The question how age-related cortical thinning and intrinsic EEG architecture relates to central hearing loss has so far not been addressed. Here, we provide the first neuroanatomical and neurofunctional evidence that cortical thinning and lateralization of speech-relevant frequency band power relates to the extent of age-related central hearing loss in older adults. The results are discussed within the current frameworks of speech processing and aging.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
06 Faculty of Arts > Institute of Psychology
08 Research Priority Programs > Dynamics of Healthy Aging
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Health Sciences > Anatomy
Life Sciences > General Neuroscience
Health Sciences > Histology
Uncontrolled Keywords:DoktoratPsych Erstautor
Language:English
Date:2018
Deposited On:28 Aug 2017 11:15
Last Modified:17 Jan 2025 02:37
Publisher:Springer
ISSN:1863-2653
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00429-017-1477-0
PubMed ID:28735495
Project Information:
  • Funder: SNSF
  • Grant ID: 105314_152905
  • Project Title: I am not too old to hear you! The role of spectral and temporal information for understanding lateralization in speech perception across the life span
  • Funder: Fonds zur Förderung des akademischen Nachwuchses’ (FAN) of the ‘Zürcher Universitätsvereins’ (ZUNIV)
  • Grant ID: K-60241-01-01
  • Project Title:
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
34 citations in Web of Science®
36 citations in Scopus®
Google Scholar™

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications