Effects of seeding adipose-derived stem cells on electrospun nanocomposite used as chest wall graft in a murine model

Abstract

OBJECTIVES Malignant neoplasms infiltrating the chest wall often requires resection of the thoracic wall. To replace the defect, Gore-Tex(®) is usually employed as the gold standard material, however, Gore-Tex(®) is inert and not degradable. Novel materials are nowadays available which allow a full bio-integration due to their non-toxic degradability. Additionally, stem cell seeding has the capacity to reduce inflammatory response towards such grafts, thus integrating it better into the host organism.