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Niewoehner, Ole; Jinek, Martin (2017). Specialized weaponry: how a type III-A CRISPR-cas system excels at combating phages. Cell Host & Microbe, 22(3):258-259.
CRISPR-Cas-mediated defense against phage invaders usually requires recognition of short sequences, termed protospacer-adjacent motifs (PAMs), in phage DNA. In this issue of Cell Host & Microbe, Pyenson et al. (2017) show that the lack of a PAM requirement in some CRISPR-Cas systems prevents interference evasion and facilitates phage extinction.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Parasitology
Life Sciences > Microbiology Life Sciences > Virology |
| Uncontrolled Keywords: | Microbiology, Parasitology, Virology |
| Language: | English |
| Date: | 13 September 2017 |
| Deposited On: | 26 Sep 2017 14:51 |
| Last Modified: | 17 Jan 2025 02:37 |
| Publisher: | Cell Press (Elsevier) |
| ISSN: | 1931-3128 |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1016/j.chom.2017.08.019 |
| PubMed ID: | 28910631 |
Niewoehner, Ole