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A cluster of scedosporiosis in lung transplant candidates and recipients: the Zurich experience and review of the literature


Abela, Irene A; Murer, Christian; Schuurmans, Macé M; Schmitt, Juergen W; Muller, Frabci; Imkamp, Frank; Mueller, Nicolas J; Benden, Christian (2018). A cluster of scedosporiosis in lung transplant candidates and recipients: the Zurich experience and review of the literature. Transplant Infectious Disease, 20(1):e12792.

Abstract

Scedosporium species are fungal pathogens increasingly recognized in cystic fibrosis (CF). They can cause multiresistant, life-threatening infections that are of particular concern in CF patients undergoing lung transplantation, as optimal treatment remains unclear. Here, we describe our Zurich experience of CF patients with Scedosporium infection. Disseminated infection occurred in one patient after transplantation and was successfully treated. We propose a step-by-step approach to treat candidates with colonization, and discuss our cases in the context of the current literature.

Abstract

Scedosporium species are fungal pathogens increasingly recognized in cystic fibrosis (CF). They can cause multiresistant, life-threatening infections that are of particular concern in CF patients undergoing lung transplantation, as optimal treatment remains unclear. Here, we describe our Zurich experience of CF patients with Scedosporium infection. Disseminated infection occurred in one patient after transplantation and was successfully treated. We propose a step-by-step approach to treat candidates with colonization, and discuss our cases in the context of the current literature.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Department of Trauma Surgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
04 Faculty of Medicine > Institute of Medical Microbiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Scedosporium , cystic fibrosis, lung transplantation, scedosporiosis
Language:English
Date:2018
Deposited On:04 Dec 2017 16:59
Last Modified:20 Feb 2018 08:57
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1398-2273
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/tid.12792
PubMed ID:29044831

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