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Individualized treatment approaches for Langerhans cell histiocytosis


Roider, E; Signer, C; Fehrenbacher, B; Metzler, G; Schaller, M; Kamarachev, J; Kerl, K; Balabanov, S; Jochum, W; Hoetzenecker, W; Cozzio, A; French, L; Dummer, R; Guenova, E (2018). Individualized treatment approaches for Langerhans cell histiocytosis. British Journal of Dermatology, 178(6):1423-1424.

Abstract

Langerhans cell histiocytosis (LCH) belongs to the rare histiocytic disorders, and has an estimated incidence of 1-2 cases per million adults [1]. Myeloid dendritic cells that express the same antigens (CD1a, CD207) as epidermal Langerhans cell seem to be the precursor cells for LCH [2]. Clinical presentation of patients with LCH may vary in site and extent of involvement. In 45% of patients LCH manifests as a multisystem disease including 77% bone, 39% skin, 19% lymph node, 16% liver, 13% spleen, 13% oral mucosa, 10% lung, and 6% CNS involvement [3]. This article is protected by copyright. All rights reserved.

Abstract

Langerhans cell histiocytosis (LCH) belongs to the rare histiocytic disorders, and has an estimated incidence of 1-2 cases per million adults [1]. Myeloid dendritic cells that express the same antigens (CD1a, CD207) as epidermal Langerhans cell seem to be the precursor cells for LCH [2]. Clinical presentation of patients with LCH may vary in site and extent of involvement. In 45% of patients LCH manifests as a multisystem disease including 77% bone, 39% skin, 19% lymph node, 16% liver, 13% spleen, 13% oral mucosa, 10% lung, and 6% CNS involvement [3]. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Dermatology
Language:English
Date:June 2018
Deposited On:21 Dec 2017 14:26
Last Modified:24 Sep 2019 22:59
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0007-0963
OA Status:Green
Publisher DOI:https://doi.org/10.1111/bjd.16171
PubMed ID:29194560

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