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Specific colorimetric detection of cyanide triggered by a conformational switch in vitamin B12


Zelder, F H (2008). Specific colorimetric detection of cyanide triggered by a conformational switch in vitamin B12. Inorganic Chemistry, 47(4):1264-1266.

Abstract

"Base on"/"base off" coordination of the intramolecular bound benzimidazole nucleobase of vitamin B 12 allows the specific colorimetric detection of millimolar concentrations of cyanide in water. In various competition experiments, it was demonstrated that up to 12 different anions as well as a 1000-fold excess of Cl (-) over CN (-) do no interfere with the sensor. An 8-fold increased sensitivity in the "naked eye" detection of CN (-) was observed when water was replaced by MeOH/H 2O (5%) as a solvent.

Abstract

"Base on"/"base off" coordination of the intramolecular bound benzimidazole nucleobase of vitamin B 12 allows the specific colorimetric detection of millimolar concentrations of cyanide in water. In various competition experiments, it was demonstrated that up to 12 different anions as well as a 1000-fold excess of Cl (-) over CN (-) do no interfere with the sensor. An 8-fold increased sensitivity in the "naked eye" detection of CN (-) was observed when water was replaced by MeOH/H 2O (5%) as a solvent.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Inorganic Chemistry
Language:English
Date:February 2008
Deposited On:20 Feb 2009 19:42
Last Modified:02 Dec 2023 02:40
Publisher:American Chemical Society
ISSN:0020-1669
OA Status:Closed
Publisher DOI:https://doi.org/10.1021/ic702368b
PubMed ID:18205304