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The need for speed: how PD1-blockade only works if T cells are properly activated


Vom Berg, Johannes; Kobold, Sebastian (2017). The need for speed: how PD1-blockade only works if T cells are properly activated. Translational Cancer Research, 6(S6):S1018-S1021.

Abstract

Programmed death receptor 1 (PD1) has been identified as critical negative regulator of T cell activity (1). While PD1-mediated T cell inhibition is an important mechanism to prevent autoimmunity, cancer and chronic infectious diseases may usurp this regulation mechanism to drive immune suppression (2). In fact, the PD1-PD-L1 axis is one of the major axis used by a variety of cancer types to inhibit T cell responses and function (3). As a direct consequence, strategies interfering with PD1-signaling such as antibodies have entered the clinic and are approved in a number of indications (4). A remarkable aspect being that these so-called check point inhibitors also show significant activity in such clinical situations where any other therapy had previously failed (5).

Abstract

Programmed death receptor 1 (PD1) has been identified as critical negative regulator of T cell activity (1). While PD1-mediated T cell inhibition is an important mechanism to prevent autoimmunity, cancer and chronic infectious diseases may usurp this regulation mechanism to drive immune suppression (2). In fact, the PD1-PD-L1 axis is one of the major axis used by a variety of cancer types to inhibit T cell responses and function (3). As a direct consequence, strategies interfering with PD1-signaling such as antibodies have entered the clinic and are approved in a number of indications (4). A remarkable aspect being that these so-called check point inhibitors also show significant activity in such clinical situations where any other therapy had previously failed (5).

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Laboratory Animal Science
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2017
Deposited On:28 Dec 2017 15:35
Last Modified:18 Apr 2018 11:49
Publisher:Pioneer Bioscience Publishing Company
ISSN:2218-676X
Funders:Wilhelm Sander Stiftung (grant number 2014.018.1), “i-Target: Immunotargeting of cancer” funded by the Elite Network of Bavaria, Melanoma Research Alliance (grant number 409510), The Marie-Sklodowska-Curie “Training Network for the Immunotherapy of Cancer (IMMUTRAIN)” funded by the H2020 program of the European Union, Else Kröner-Fresenius-Stiftung, German Cancer Aid, Ernst-Jung-Stiftung, LMU Munich’s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative and the Bundesministerium für Bildung und Forschung., University of Zurich (FK-15-057), Novartis Foundation for medical-biological Research (16C231), Swiss Cancer Research (KFS-3852-02-2016)
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.21037/tcr.2017.06.55
Project Information:
  • : Funder
  • : Grant ID
  • : Project TitleWilhelm Sander Stiftung (grant number 2014.018.1)
  • : Funder
  • : Grant ID
  • : Project Title“i-Target: Immunotargeting of cancer” funded by the Elite Network of Bavaria
  • : Funder
  • : Grant ID
  • : Project TitleMelanoma Research Alliance (grant number 409510)
  • : FunderH2020
  • : Grant ID
  • : Project TitleThe Marie-Sklodowska-Curie “Training Network for the Immunotherapy of Cancer (IMMUTRAIN)” funded by the H2020 program of the European Union
  • : Funder
  • : Grant ID
  • : Project TitleElse Kröner-Fresenius-Stiftung
  • : Funder
  • : Grant ID
  • : Project TitleGerman Cancer Aid
  • : Funder
  • : Grant ID
  • : Project TitleErnst-Jung-Stiftung
  • : Funder
  • : Grant ID
  • : Project TitleLMU Munich’s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative and the Bundesministerium für Bildung und Forschung.
  • : Funder
  • : Grant ID
  • : Project TitleUniversity of Zurich (FK-15-057)
  • : Funder
  • : Grant ID
  • : Project TitleNovartis Foundation for medical-biological Research (16C231)
  • : Funder
  • : Grant ID
  • : Project TitleSwiss Cancer Research (KFS-3852-02-2016)

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