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Modelling attention-deficit hyperactivity disorder: From hair follicles to neurons using induced pluripotent stem cells


Re, Silvano; Werling, Anna; Berger, Gregor; Walitza, Susanne; Grünblatt, Edna (2017). Modelling attention-deficit hyperactivity disorder: From hair follicles to neurons using induced pluripotent stem cells. Leading Opinions Neurologie & Psychiatrie, 17(5):31-33.

Abstract

Despite tremendous research efforts, the exact causative mechanisms of attention-deficit hyperactivity disorder (ADHD) still have to be elucidated. One major challenge is the difficulty to reflect the complexity and simultaneously the individual features of ADHD with the current in vitro or in vivo model systems. A new strategy to circumvent this problem is to develop a patient specific research model of a «small personalized brain» in a dish using the induced pluripotent stem cell technology. This approach has now been initiated for the first time in Switzerland at the Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich.

Abstract

Despite tremendous research efforts, the exact causative mechanisms of attention-deficit hyperactivity disorder (ADHD) still have to be elucidated. One major challenge is the difficulty to reflect the complexity and simultaneously the individual features of ADHD with the current in vitro or in vivo model systems. A new strategy to circumvent this problem is to develop a patient specific research model of a «small personalized brain» in a dish using the induced pluripotent stem cell technology. This approach has now been initiated for the first time in Switzerland at the Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich.

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Additional indexing

Item Type:Journal Article, not_refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Center for Child and Adolescent Psychiatry
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2017
Deposited On:28 Dec 2017 09:31
Last Modified:19 Mar 2018 09:27
Publisher:Universimed Cross Media Content
ISSN:1608-8964
OA Status:Green
Official URL:http://ch.universimed.com/fachthemen/8562

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