Header

UZH-Logo

Maintenance Infos

Primary treatment choice over time and relative survival of prostate cancer patients: influence of age, grade, and stage


Matthes, Katarina L; Limam, Manuela; Dehler, Silvia; Korol, Dimitri; Rohrmann, Sabine (2017). Primary treatment choice over time and relative survival of prostate cancer patients: influence of age, grade, and stage. Oncology Research and Treatment, 40(9):484-489.

Abstract

BACKGROUND: The aim of this study was to assess associations of stage, grade, and age with the primary treatment of prostate cancer (PCa) patients comparing the incidence years 2000/2001 and 2012/2013, and to estimate the relative survival (RS) for patients diagnosed in 2000/2001.
METHODS: We included 1,541 men diagnosed in 2000/2001 and 1,605 men diagnosed in 2012/2013. Multiple imputation methods were applied to missing data for stage and grade. Multinomial logistic regression analyses were used to explore the associations of stage, grade, and age with treatment. RS was estimated using the Ederer II approach.
RESULTS: In 2000/2001, older patients were more likely to choose active surveillance (AS)/watchful waiting (WW) or to receive androgen deprivation therapy (ADT) compared to surgery; in 2012/2013, this association was only observed for ADT but not for AS/WW. In 2000/2001, the overall 1-, 5-, and 10-year RS was approximately 99, 94, and 92%, respectively. RS was highest for patients who underwent surgical procedures or radiotherapy and considerably lower for patients with ADT.
CONCLUSION: Our data show that today AS/WW is an option not only for patients with a life expectancy of < 10 years but also for younger men with localized PCa. PCa patients have a good RS if the cancer is diagnosed at an early stage.

Abstract

BACKGROUND: The aim of this study was to assess associations of stage, grade, and age with the primary treatment of prostate cancer (PCa) patients comparing the incidence years 2000/2001 and 2012/2013, and to estimate the relative survival (RS) for patients diagnosed in 2000/2001.
METHODS: We included 1,541 men diagnosed in 2000/2001 and 1,605 men diagnosed in 2012/2013. Multiple imputation methods were applied to missing data for stage and grade. Multinomial logistic regression analyses were used to explore the associations of stage, grade, and age with treatment. RS was estimated using the Ederer II approach.
RESULTS: In 2000/2001, older patients were more likely to choose active surveillance (AS)/watchful waiting (WW) or to receive androgen deprivation therapy (ADT) compared to surgery; in 2012/2013, this association was only observed for ADT but not for AS/WW. In 2000/2001, the overall 1-, 5-, and 10-year RS was approximately 99, 94, and 92%, respectively. RS was highest for patients who underwent surgical procedures or radiotherapy and considerably lower for patients with ADT.
CONCLUSION: Our data show that today AS/WW is an option not only for patients with a life expectancy of < 10 years but also for younger men with localized PCa. PCa patients have a good RS if the cancer is diagnosed at an early stage.

Statistics

Citations

Dimensions.ai Metrics
1 citation in Web of Science®
1 citation in Scopus®
1 citation in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

6 downloads since deposited on 28 Dec 2017
6 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Active surveillance, Cancer registry, Prostate cancer, Survival analysis, Time trends, Treatment
Language:English
Date:2017
Deposited On:28 Dec 2017 16:34
Last Modified:17 Aug 2018 00:00
Publisher:Karger
ISSN:2296-5270
OA Status:Green
Publisher DOI:https://doi.org/10.1159/000477096
PubMed ID:28813713

Download

Download PDF  'Primary treatment choice over time and relative survival of prostate cancer patients: influence of age, grade, and stage'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 85kB
View at publisher