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The 1-min sit-to-stand test in cystic fibrosis - Insights into cardiorespiratory responses


Radtke, Thomas; Hebestreit, Helge; Puhan, Milo A; Kriemler, Susi (2017). The 1-min sit-to-stand test in cystic fibrosis - Insights into cardiorespiratory responses. Journal of Cystic Fibrosis, 16(6):744-751.

Abstract

BACKGROUND: We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (PowerSTS) as a measure of exercise capacity.
METHODS: Fifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis.
RESULTS: Peak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r=0.69-0.98) with those measured during the CPET. Oxygen uptake, carbon dioxide production, heart rate, ventilation, and tidal volume at peak exercise were 24%, 26%, 9%, 10% and 21% lower in the 1-min STS test, while respiratory frequencies were 14% higher. PowerSTS showed strong to very strong correlations with CPET-derived absolute peak oxygen uptake and maximal workload.
CONCLUSIONS: The 1-min STS test elicits a substantial but lower cardiorespiratory response compared to a maximal cycle ergometry CPET. While PowerSTS and STS repetitions are both valid outcome measures of functional capacity, STS repetitions are clinically more practical.

Abstract

BACKGROUND: We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (PowerSTS) as a measure of exercise capacity.
METHODS: Fifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis.
RESULTS: Peak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r=0.69-0.98) with those measured during the CPET. Oxygen uptake, carbon dioxide production, heart rate, ventilation, and tidal volume at peak exercise were 24%, 26%, 9%, 10% and 21% lower in the 1-min STS test, while respiratory frequencies were 14% higher. PowerSTS showed strong to very strong correlations with CPET-derived absolute peak oxygen uptake and maximal workload.
CONCLUSIONS: The 1-min STS test elicits a substantial but lower cardiorespiratory response compared to a maximal cycle ergometry CPET. While PowerSTS and STS repetitions are both valid outcome measures of functional capacity, STS repetitions are clinically more practical.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Pulmonary and Respiratory Medicine
Language:English
Date:November 2017
Deposited On:02 Jan 2018 21:52
Last Modified:28 Jul 2020 12:21
Publisher:Elsevier
ISSN:1569-1993
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.jcf.2017.01.012
PubMed ID:28188010

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