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Retrospective clinical study on outcome in cats with nasal planum squamous cell carcinoma treated with an accelerated radiation protocol


Gasymova, Evgeniya. Retrospective clinical study on outcome in cats with nasal planum squamous cell carcinoma treated with an accelerated radiation protocol. 2017, University of Zurich, Vetsuisse Faculty.

Abstract

Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a valuable treatment option. The aim of the current study was to evaluate outcome and toxicity, as well as possible prognostic factors using an accelerated hypofractionated radiation therapy protocol. Cats treated with an accelerated radiation protocol (10 × 4.8 Gy) were retrospectively evaluated. Tumor- and treatment-associated variables were evaluated in respect to local control and survival.
Forty-four cats met the inclusion criteria for this study. All cats showed complete response to therapy. Median disease-free interval (DFI) for all cases was 916 days. Of the tested variables, only tumor volume showed a tendency to influence DFI. Median overall survival (OS) was 902 days. Of the tested variables, again, only tumor volume influenced OS. The acute and late toxicity profile was low and hence clinically acceptable.
Conclusion: Curative-intent radiation therapy with accelerated fractionation schedule can be considered a safe, cosmetically superior treatment option for cutaneous squamous cell carcinomas of the nasal planum in cats, resulting in long and stable tumor control.

Abstract

Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a valuable treatment option. The aim of the current study was to evaluate outcome and toxicity, as well as possible prognostic factors using an accelerated hypofractionated radiation therapy protocol. Cats treated with an accelerated radiation protocol (10 × 4.8 Gy) were retrospectively evaluated. Tumor- and treatment-associated variables were evaluated in respect to local control and survival.
Forty-four cats met the inclusion criteria for this study. All cats showed complete response to therapy. Median disease-free interval (DFI) for all cases was 916 days. Of the tested variables, only tumor volume showed a tendency to influence DFI. Median overall survival (OS) was 902 days. Of the tested variables, again, only tumor volume influenced OS. The acute and late toxicity profile was low and hence clinically acceptable.
Conclusion: Curative-intent radiation therapy with accelerated fractionation schedule can be considered a safe, cosmetically superior treatment option for cutaneous squamous cell carcinomas of the nasal planum in cats, resulting in long and stable tumor control.

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Additional indexing

Item Type:Dissertation (monographical)
Referees:Rohrer Bley Carla
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
UZH Dissertations
Dewey Decimal Classification:630 Agriculture
Uncontrolled Keywords:Plattenepithelkarzinom, Strahlentherapie, Katze, Nasal squamous cell carcinoma, Radiation therapy, Cat
Language:English
Place of Publication:Zürich
Date:2017
Deposited On:12 Jan 2018 11:42
Last Modified:28 Feb 2020 16:54
Number of Pages:13
Additional Information:Publiziert in: BMC veterinary research 2017 Apr 4;13(1):86
OA Status:Green
Free access at:PubMed ID. An embargo period may apply.
Related URLs:https://www.recherche-portal.ch/permalink/f/5u2s2l/ebi01_prod010997652 (Library Catalogue)

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