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Novel hyperthermia applicator system allows adaptive treatment planning: preliminary clinical results in tumor-bearing animals


Dressel, Susann. Novel hyperthermia applicator system allows adaptive treatment planning: preliminary clinical results in tumor-bearing animals. 2017, University of Zurich, Vetsuisse Faculty.

Abstract

Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality treatment method to enhance therapeutic efficacy in different tumors. High demands are placed on the hardware and treatment planning software to guarantee adequately planned and applied HT treatments. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumor-bearing dogs and cats in terms of local response and toxicity as well as to compare planned with actual achieved data during heating. A novel applicator with a flexible number of elements and integrated closed-loop temperature feedback control system, and a tool for patient-specific treatment planning were used in a combined thermoradiotherapy protocol. Good agreement between predictions from planning and clinical outcome was found in 7 of 8 cases. Effective hyperthermia treatments led to enhanced local responses and provided improved quality of life in all but one patients. This individualized treatment planning and controlled heat exposure allows adaptive, flexible and safe HT treatments in palliatively treated animal patients.

Abstract

Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality treatment method to enhance therapeutic efficacy in different tumors. High demands are placed on the hardware and treatment planning software to guarantee adequately planned and applied HT treatments. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumor-bearing dogs and cats in terms of local response and toxicity as well as to compare planned with actual achieved data during heating. A novel applicator with a flexible number of elements and integrated closed-loop temperature feedback control system, and a tool for patient-specific treatment planning were used in a combined thermoradiotherapy protocol. Good agreement between predictions from planning and clinical outcome was found in 7 of 8 cases. Effective hyperthermia treatments led to enhanced local responses and provided improved quality of life in all but one patients. This individualized treatment planning and controlled heat exposure allows adaptive, flexible and safe HT treatments in palliatively treated animal patients.

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Additional indexing

Item Type:Dissertation
Referees:Rohrer Bley Carla
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2017
Deposited On:25 Jan 2018 10:12
Last Modified:20 Sep 2018 04:27
Funders:Marie-Louise von Muralt-Stiftung für Kleintiere
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/vco.12340
Related URLs:https://www.zora.uzh.ch/id/eprint/139628/
Other Identification Number:PubMed ID:28892246

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